Repair & Regeneration
GHK-Cu
A copper peptide you rub on to rebuild collagen and firm tired skin.
GHK-Cu is a copper-binding tripeptide your skin makes naturally and loses as you age. Rubbed on as a cream, it carries copper into skin cells and signals the fibroblasts that build connective tissue to make more collagen and elastin. The one option in this category you apply instead of inject.
- Physician-reviewed before it ships
- Prescription required
- $60/mo membership, cancel anytime
GHK-Cu is a copper-binding tripeptide (glycyl-L-histidyl-L-lysine) that your skin and blood make naturally, and that falls as you age. Applied as a cream, it carries copper into skin cells, where it signals fibroblasts (the cells that build connective tissue) to make more collagen, elastin, and the gel-like molecules that keep skin plump. That is a different job than a moisturizer: instead of sitting on top of the skin, it acts on the cells that build the skin's structure. Pru offers compounded GHK-Cu prepared at FDA-registered compounding pharmacies under a physician's prescription. That describes the pharmacy, not an FDA-approved cosmetic; this is a compounded topical.
For you if the goal is how your face looks: firmer skin, fewer fine lines, better texture, and faster fading of scars and post-procedure redness. Especially if creams have not moved the needle and your skin looks tired or crepey.
This is the only skin-appearance peptide in the Repair and Regeneration set, and the only one you rub on instead of inject. It does not overlap with the tendon and gut recovery molecules (BPC-157, TB-500). It is also the one item here with placebo-controlled cosmetic trials behind it. If the question is how your face looks, this is the answer.
Studied in placebo-controlled cosmetic trials for skin firmness, fine lines, texture, and density, and for fading of scars and post-procedure redness. Research suggests it works by signaling fibroblasts to rebuild collagen and elastin. This is a gradual, visible change over roughly 12 weeks, not a same-day effect. Individual results vary and require physician oversight.
Pick a starting option.
A starting point, not a final prescription. Your physician confirms the right form, strength, and dose during consultation, which can change the price you pay.
The medicine is one input. The program is the rest.
What you might notice, how you track it honestly, and how Pru and your clinician work with you. Individual results vary.
What you would notice
If it works as intended, many people describe firmer, smoother, denser skin over about 12 weeks, with marks and redness fading faster than they would on their own. This is a gradual visible change, not a same-day result. Some people notice mild, transient stinging, redness, or tingling at first (more likely at higher concentration or on freshly exfoliated skin), and a temporary greenish-blue tint at the application site from the copper, which fades by morning.
How you track it
You track it with standardized in-app photos at day 0, 30, 60, and 90, shot at a fixed distance, lighting, and angle so the change is real and not a trick of the light. For scars, you also log the POSAS patient scale, judged at the 8 to 12 week mark. Because the change is gradual, the photo timeline is what makes progress visible.
How Pru works with you
Pru turns the cream into a program, and a clinician adjusts it with you. The routine: nightly application on clean skin, daily SPF because UV degrades the new collagen you are building, and keeping vitamin C and acids in a separate routine so they do not destabilize the copper. Most people start at the gentler 0.5% strength. A clinician reviews your skin first, sets a safety gate (hold on broken, actively inflamed, or reactive skin until the barrier is treated, and avoid entirely with a known copper or peptide allergy), and helps you titrate strength as your skin tolerates it.
A horizon, personalized to you.
Not a promise. Your clinician personalizes the plan and tracks how you respond. Individual results vary.
- Weeks 1–2
Getting started
Your clinician sets a starting protocol and decides whether any initial titration is right for you. The early window is about onboarding and tolerability: dialing in dose, timing, and technique together.
- Weeks 3–6
Finding your rhythm
Many people describe settling into a consistent routine across these weeks while their clinician reviews how they are responding and adjusts as needed.
- Month 2+
Maintenance
Most protocols move to a steady maintenance cadence guided by your clinician. Check-ins are where dose, frequency, and format are reviewed against what you are noticing.
A physician reviews every order. The medicine is sold at cost.
You are not buying off a shelf. A licensed physician reviews your health profile and decides whether GHK-Cu is right for you. If it is, you pay exactly what it costs us. The pharmacy fill, the supplies, your consult, shipping. Nothing on top. Your membership is the only thing you pay for.
- Reviewed by a licensed physician before anything ships
- Compounded by FDA-registered pharmacies, tested for purity
- Itemized at-cost pricing, no markup on the medicine
- Ongoing clinical support included in membership
Built around you, not a catalog.
The off-the-shelf way
- One fixed dose for everyone
- Opaque sticker price, hidden markup
- Buy it and you're on your own
- One delivery form, take it or leave it
- A catalog, no one reviewing your fit
The Pru way
- Dose titrated by your physician
- Medication at cost, itemized in full
- Ongoing clinical check-ins, included
- Form matched to your routine
- A physician reviews before it ships
Everything you need to know.
Do I need a prescription?
Yes. Every peptide at Pru is physician-prescribed and dispensed through FDA-registered compounding pharmacies. There is no over-the-counter path. It starts with your membership, which unlocks a medical intake and a review by a licensed physician who decides whether it is appropriate for you.
Are peptides safe?
Peptides are prescription medications. They are compounded by FDA-registered pharmacies and tested for purity and sterility, and your physician reviews your health history to determine whether they are appropriate for you. They are not right for everyone, and individual results vary.
How long until I notice anything?
It varies by person and by peptide, and we will not promise a timeline. Your physician sets expectations during review and tracks how you respond over time. Some people describe changes over weeks to months; individual results vary.
Is lab work required?
It depends. Lab work is a clinical decision made by your physician, not a fixed requirement for everyone. During your intake and review, the physician determines whether labs are needed before prescribing, based on your individual situation, and will tell you what is needed and why.
More questions? Visit the help center.
Ready when you are
Start with GHK-Cu.
Add it to your cart and complete a short intake. A physician confirms the fit. You only pay if it is prescribed.