The Pru Brief

The science of
optimization.

Evidence-based insights on peptide therapy, longevity, and the future of health. No noise — just research you can use.

11Issues Published
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No. 11Science7 min read

Tesamorelin: the most targeted growth hormone peptide in clinical use

FDA-approved, precisely studied, and built for a specific kind of fat that diet and exercise struggle to reach.

No. 10Science7 min read

Sermorelin: the case for working with your body own growth hormone

Your pituitary still knows how to make growth hormone. Sermorelin simply reminds it to.

No. 09Science8 min read

Tirzepatide: the dual-action drug rewriting the rules of metabolic medicine

It targets two hormones at once — and the results are unlike anything seen before in obesity medicine.

No. 08Science8 min read

Semaglutide: what it actually does inside your body

The science behind the most-discussed drug in a generation — and what it means beyond weight loss.

No. 07Foundations5 min read

Peptides vs. steroids: why they're not the same thing

The differences in how they work, what they do to your body, and why the distinction matters for your health.

No. 06Foundations6 min read

Injection basics: what to know before your first protocol

Subcutaneous technique, reconstitution, storage, and what to expect — explained plainly and completely.

No. 05Science5 min read

Peptides and longevity: what the science actually says

Your body already makes the molecules that regulate how you age. Here's what researchers are learning about them — and what it could mean for you.

No. 04Science5 min read

Why your body does its best repair work while you sleep

You've probably heard that sleep is important. But the reason goes deeper than most people realize — and it connects directly to peptides.

No. 03Culture5 min read

Who is talking about peptides, and what are they actually saying?

A careful look at the public figures driving the peptide conversation — what they have said on the record, and how to think about it.

No. 02Regulatory5 min read

The FDA reversal, explained

What the 2023 peptide ban was, why it happened, what changed in 2026, and what it means for you.

No. 01Foundations4 min read

What are peptides, really?

A plain-English introduction to the molecules at the center of modern personalized medicine.

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