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Top 4 Sesame Alternatives in 2026

Sesame stepped back from compounded GLP-1 and is now a marketplace for cash-pay visits. If that is why you are here, this is where the real alternatives stand today, ranked by what you pay all in.

By the pru team  ·  Updated July 9, 2026  ·  7-minute read
A warm, colorful photo of a smiling, healthy adult in a sunlit kitchen, relaxed and confident, the kind of person comparing providers and ready to switch
Image: pru

If you came to Sesame for compounded GLP-1 and found it gone, you are not alone. In 2026 Sesame discontinued compounded GLP-1 and repositioned as a marketplace for cash-pay medical visits, and several other big names stepped back from compounding at the same time. The good news: a handful of providers still compound, and the clearest way to compare them is the medicine itself, priced at cost, not the headline sticker.

On that measure pru's compounded semaglutide is about $60 a month, your price per month when you start on a 3-month plan, at cost with no markup on the medicine, the lowest medication price we found. pru's membership is separate: $50 a month billed annually for unlimited access. Here is the full picture, including the other real alternatives.

Sesame alternatives at a glance

The clearest way to sort these providers is the medicine itself, priced at cost. Several providers advertise a low medicine price and then add a separate membership as their real margin, so the sticker number and what you pay are not the same. pru is different: the medicine is at cost with no markup, and the flat $50 membership buys unlimited access to the platform and clinician messaging, not a marked-up vial.

Because the membership is unlimited and every peptide is at cost, the savings compound with each vial and you can stack more than one peptide without a markup on any of them.

~$60/mo
pru's compounded semaglutide at cost, your price per month when you start on a 3-month plan, the lowest medication price we found; membership separate
4
major brands that exited compounded GLP-1 in 2025 and 2026: Hims, Ro, WeightWatchers, Sesame
$99-397
typical all-in range at providers still compounding, most landing at $199-299
Sources: provider pricing pages and 2026 settlement announcements. See sources below.
ProviderMonthly costWhat is included
pruabout $60 medicationCompounded semaglutide at cost with no markup, about $60 a month when you start on a 3-month plan (tirzepatide about $93); the $50 monthly membership is separate and buys unlimited at-cost access; licensed physician confirms fit, FDA-registered 503A pharmacy compounds and fills, Certificate of Analysis included
Edenabout $198$99 medicine plus a separate $99 membership; polished app and intake, physician visit and compounded GLP-1 included once both fees are counted
Other compounding providers (typical)$199-299Most cluster here once the program or membership fee is added to the medicine, often bundling coaching, lifestyle programs, or broader treatment menus that some people value; a few premium programs reach as high as $397
Sesamenot offeredDiscontinued compounded GLP-1 in 2026; now a marketplace for cash-pay medical visits, so you would still need a separate provider to fill compounded GLP-1
For providers that split medicine and membership, all-in cost means medicine plus that fee. pru's figure is its semaglutide at cost when you start on a 3-month plan; pru's $50 membership is separate and unlimited. Sesame no longer offers compounded GLP-1.

Why people are looking for a Sesame alternative now

Sesame built a useful thing: a marketplace where you can book a cash-pay medical visit without insurance, often at a transparent price. That part still works, and for a one-off appointment it is a fair option. What changed is compounded GLP-1. In 2026 Sesame discontinued it.

Sesame was not alone. In 2025 and 2026, Hims, Ro, and WeightWatchers all exited compounded GLP-1 as well, as the FDA declared the semaglutide and tirzepatide shortages resolved. If you were relying on any of them for a monthly compounded semaglutide or tirzepatide fill, the program you signed up for is gone, which is why so many people are comparing alternatives at once.

WHAT THIS MEANS FOR YOUSesame is still a solid marketplace for cash-pay visits. It is no longer a place to get compounded GLP-1, so if that is what you need, you need a provider that still compounds.

How to compare the alternatives plainly

Once you start shopping, the prices look wildly different, and most of that is packaging, not real cost. Four things separate a good compounded GLP-1 provider from a risky one.

  • The all-in price, not the headline. Add the medicine and any membership or program fee together. A $99 medicine with a $99 membership is a $198 provider. Compare like with like.
  • Who prescribes and who fills. A licensed physician should review your history and confirm the medicine is appropriate for you, and an FDA-registered 503A pharmacy should compound it. Both matter.
  • Proof of what is in the vial. A Certificate of Analysis documents the contents of what you are injecting. It should come standard, not on request.
  • Where the medicine comes from. If a site sells GLP-1 with no prescription and no named pharmacy, that is the grey market, and price is not the reason to be there.

THE ONE NUMBER THAT MATTERSMedicine price plus any membership or program fee equals your real monthly cost, so always read the total for a split-price provider. For pru we compare on the medicine itself, because it is at cost and the membership is unlimited.

Why pru is the at-cost benchmark

pru is a LegitScript-certified telehealth membership built around one idea: offer the medicine at cost and make money only on a flat membership, never on a markup. That is why pru's compounded semaglutide comes to about $60 a month, your price per month when you start on a 3-month plan, the lowest medication price of any compounded provider we found. The $50 membership is separate: it is billed annually and buys unlimited at-cost access to the platform and clinician messaging, so nothing is marked up behind it.

  • At cost, itemized. The compounded semaglutide is priced at cost with no markup on the medicine. You see what it costs.
  • A licensed physician confirms fit. A physician reviews your history and confirms the medicine is appropriate for you, or advises against it, and sets your dose.
  • An FDA-registered 503A pharmacy fills it. Your prescription is compounded and filled by an FDA-registered 503A pharmacy, with a Certificate of Analysis documenting what is inside.
  • One flat membership. The $50 monthly membership, billed annually, funds unlimited at-cost access to the platform and clinician messaging. Because every peptide is at cost, the savings compound with each vial and you can stack more than one peptide without a markup on any of them.

Compounded medicines like this are pharmacy-grade, meaning a physician prescribed them and a licensed pharmacy prepared them for you as an individual. They are not FDA-approved finished products, and pru does not describe them as the same as any branded drug.

Taking charge of your metabolic health is a smart, responsible move, and pru exists to keep that proactive choice within reach: the licensed physician, the 503A pharmacy, and at-cost pricing make the careful path the accessible one. See the weight loss & metabolism category and the at-cost pricing for what is available now.

The other real alternatives, fairly

pru is not the only provider still compounding, and a fair guide names the others. Here is where they stand.

  • Eden. Eden is a real, established telehealth brand that still offers compounded GLP-1, with a polished intake, a well-built app, and responsive support, so someone who wants a familiar, name-brand experience and a smooth onboarding will find it a sensible choice. The pricing structure is what to know: the advertised $99 medicine sits alongside a separate $99 membership, so the all-in cost is about $198 per month, a fair price for a well-run program. On the medicine itself, Eden's $99 semaglutide sits above pru's roughly $60 at-cost price, and where Eden's membership marks up a single vial, pru's membership is unlimited at-cost access.
  • Other compounding telehealth providers. A group of providers still compound GLP-1 and most land at $199-299 all in once the program fee is counted, with a few premium programs reaching as high as $397. Several bundle real extras that some people want and will happily pay for: hands-on coaching from a dietitian or nurse, structured lifestyle programs, broader treatment menus beyond GLP-1, or help navigating insurance for a branded drug when that path fits. If high-touch support or a one-stop menu matters more to you than the lowest medicine price, one of these can be the right fit. Several use the same split-price structure, a low medicine price with a separate membership, so read the total carefully.
  • Sesame itself, for visits. If what you need is a one-off cash-pay medical appointment rather than an ongoing compounded fill, Sesame's marketplace is still a good tool for exactly that. Its transparent, insurance-free booking is a real strength, and it remains a sensible choice for a single visit.

THE FAIR SUMMARYAny of these can be a reasonable choice, and several are well run. On the medicine itself, priced at cost, pru's compounded semaglutide is the lowest we found at about $60 a month when you start on a 3-month plan, with the physician review, 503A pharmacy, and Certificate of Analysis included; the $50 membership is separate and unlimited. If you were proactive enough to compare providers instead of settling, take the next step when you are ready and pick the one that keeps that smart choice affordable.

The one alternative to avoid: the grey market

When a program you trusted goes away, the tempting shortcut is a website selling GLP-1 vials with no prescription, no named pharmacy, and no clinician, often labeled "for research use only." The price looks great. Everything else is missing. There is no physician confirming the medicine is right for you, no licensed pharmacy standing behind how it was made, and no Certificate of Analysis telling you what is in the vial.

THE REAL DIVIDEThe same molecule can reach you two ways: as an unregulated research chemical with no oversight, or as a prescribed, 503A pharmacy-made medicine documented with a Certificate of Analysis. pru only does the second, and so should any alternative you choose.

Common questions

Why did Sesame stop offering compounded GLP-1?
In 2026 Sesame discontinued compounded GLP-1 and repositioned as a marketplace for cash-pay medical visits. It was part of a wider shift: Hims, Ro, and WeightWatchers also exited compounded GLP-1 in 2025 and 2026, as the FDA declared the semaglutide and tirzepatide shortages resolved. Sesame's visit marketplace still works; it just no longer fills compounded GLP-1.
What is the closest alternative to Sesame for compounded GLP-1?
For an ongoing compounded semaglutide fill, pru is the lowest-cost alternative we found on the medicine itself: about $60 a month for semaglutide, your price per month when you start on a 3-month plan, priced at cost with a licensed physician confirming fit and an FDA-registered 503A pharmacy filling it with a Certificate of Analysis. pru's $50 membership is separate and buys unlimited at-cost access. Eden still compounds too, at about $198 all in once its separate membership is counted.
Why is pru cheaper than most Sesame alternatives?
pru offers the medicine at cost with no markup and makes money only on a flat membership. Many other providers advertise a low medicine price and add a separate membership or program fee as their real margin, so their all-in cost lands at $199-299. pru's compounded semaglutide is about $60 a month at cost, your price per month when you start on a 3-month plan, and its $50 membership is separate and unlimited, so the savings compound with every vial and you can stack more than one peptide without a markup on any of them.
Is Eden a good Sesame alternative?
Eden is a real, well-built telehealth brand that still offers compounded GLP-1, so it is a genuine option. The main thing to know is the pricing: its roughly $99 medicine comes with a separate roughly $99 membership, so the all-in cost is about $198 per month. On the medicine itself, Eden's $99 semaglutide sits above pru's roughly $60 at-cost price, and where Eden's membership marks up a single vial, pru's $50 membership is unlimited at-cost access.
Are pru's compounded peptides FDA-approved?
No. pru dispenses 503A pharmacy-grade compounded medicine, prescribed by a licensed physician and prepared by an FDA-registered 503A pharmacy for you as an individual, with a Certificate of Analysis. Compounded medicines are legitimate and overseen, but they are not FDA-approved as finished products, and pru does not describe them as the same as any branded drug.
Can I still use Sesame for anything?
Yes. Sesame remains a useful marketplace for booking cash-pay medical visits without insurance, often at a transparent price. It is no longer a place to get compounded GLP-1, so if that is what you need, you will use a provider that still compounds, such as pru, and can book a visit through Sesame separately if you ever want a one-off appointment.
How does pru keep peptides affordable?
pru runs on an at-cost model. You pay one flat membership, and the medication is passed through at the pharmacy's price with no member markup. Because pru never marks the medication up, we have every reason to push its price down, not up. As pru grows and orders more, we negotiate lower pricing with our partner pharmacies, and those savings go straight to you. Healthcare pricing is usually hidden and inflated; pru is built to sit on your side of it: transparent, at cost, and fighting to make peptides more affordable as we scale.
Do the savings add up if I take more than one peptide?
Yes, and this is where pru's at-cost pricing saves you the most. Because pru never marks the medication up, every vial is priced at cost, so each peptide you add avoids the markup a typical provider builds in. If a physician has you on more than one peptide, or on a stack, that saving repeats on every vial, all under one flat $50 membership instead of a marked-up price on each. The more your protocol includes, the more the difference adds up, which makes doing it the right way a financially responsible choice, not an expensive one.
Sources & further reading
  1. pru catalog, category, and pricing pages. joinpru.com. Accessed July 2026.
  2. U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers (503A compounded drugs). fda.gov. Accessed July 2026.
  3. U.S. Food and Drug Administration. Human Drug Compounding. fda.gov. Accessed July 2026.
  4. 2025 and 2026 compounded GLP-1 market exits (Hims, Ro, WeightWatchers, Sesame) as the FDA declared the semaglutide and tirzepatide shortages resolved. Company announcements, 2025 and 2026.
  5. Compounded GLP-1 provider pricing survey, 2026 (all-in monthly cost range $99-397, most $199-299; split medicine-plus-membership structures such as Eden). Provider pricing pages, accessed July 2026.

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