Cellular Health & Longevity
NAD+
Top up the cellular fuel that fades with age.
NAD+ is the fuel your cells use to make energy, repair their own DNA, and run the body's longevity pathways. Levels fall as you get older. This is a physician-prescribed way to top them back up, by subcutaneous injection or nasal spray.
- Physician-reviewed before it ships
- Prescription required
- $60/mo membership, cancel anytime
How NAD+ works
Start here
What is NAD⁺?
It is one of the molecules your body uses to turn food into the energy that powers every cell, every day. You have never had to think about it. It just works.
Why it matters
It is how your cells make energy.
When you feel sharp, recover quickly, and move through a day with ease, this is some of the quiet machinery behind it. NAD⁺ is studied for its central role in how cells produce energy.
The bigger picture
Energy. Recovery. Repair.
Research connects NAD⁺ to the way cells make energy, repair their own DNA, and maintain themselves over time. It is part of the foundation, not a quick fix.
The catch
It fades as we get older.
Research shows NAD⁺ levels tend to decline with age, which is why it has drawn so much interest. The science is still developing, and Pru does not claim NAD⁺ reverses aging or treats any disease.
This is for you if your main complaint is plain fatigue: tired all the time, slow to recover, low daily energy, and you want to restore the cellular fuel that drops with age. If "I am run down and my recovery is slow" is the line that fits you, start here.
NAD+ is the actual fuel of the Cellular Health & Longevity category. It runs the enzymes that repair DNA and the sirtuins behind your longevity pathways. Its sibling, glutathione, protects and detoxifies rather than fuels. Pick NAD+ when the complaint is plain fatigue and low energy. Pick glutathione when it is oxidative stress, recovery, or skin tone.
2 forms. 3 options.
A starting point, not a final prescription. Your physician confirms the right form, strength, and dose during consultation, which can change the price you pay.
The medicine is one input. The program is the rest.
What you might notice, how you track it honestly, and how Pru and your clinician work with you. Individual results vary.
What you would notice
If it works as intended, many people describe more daytime energy, faster recovery, and a generally younger, steadier feeling, often within the first few weeks. The gains tend to be concentrated in older adults, where NAD+ has fallen the most. This is an experience people report, not a guaranteed result, and it builds gradually rather than switching on overnight.
How you track it
You track it with an energy and fatigue questionnaire at weeks 4, 8, and 12, plus a quick weekly micro-log so you can see the trend rather than guess from memory. Give it 8 to 12 weeks. NAD+ tends to build slowly, so the calendar is set up to tell a real slow climb apart from no response.
How Pru works with you
Pru pairs the medicine with the program around it. We pair NAD+ with the exercise program, because resistance training and zone-2 cardio are a well-supported way to raise your own NAD+, so the molecule and your habits pull in the same direction. Your clinician times the dose to the morning and splits higher doses to keep levels steady and ease the flushing. We set an 8 to 12 week expectation calendar so a slow build is not mistaken for failure, and your clinician reviews your tracking and adjusts the plan as you go. A flushing or warm pressure feeling can come on during and right after a dose and usually settles in 15 to 45 minutes; the nasal spray can sting briefly. We talk you through what to expect so none of it is a surprise. NAD+ is not given in the same line as glutathione, and it is avoided in pregnancy and breastfeeding; your clinician reviews any cancer history at intake before starting.
A horizon, personalized to you.
Not a promise. Your clinician personalizes the plan and tracks how you respond. Individual results vary.
- Weeks 1–2
Loading and onboarding
Your clinician sets a starting protocol and decides whether an initial loading schedule is right for you. This window is about onboarding and tolerability: dialing in dose, timing, and injection or nasal-spray technique together.
- Weeks 3–6
Finding your rhythm
These molecules are studied for their role in cellular energy metabolism and how those pathways shift with age. Across these weeks, many people describe settling into a consistent routine while their clinician reviews how they respond.
- Month 2+
Maintenance
Most protocols transition to a steady maintenance cadence guided by your clinician. Check-ins are where dose, frequency, and format are reviewed against what you are noticing.
A physician reviews every order. The medicine is sold at cost.
You are not buying off a shelf. A licensed physician reviews your health profile and decides whether NAD+ is right for you. If it is, you pay exactly what it costs us. The pharmacy fill, the supplies, your consult, shipping. Nothing on top. Your membership is the only thing you pay for.
- Reviewed by a licensed physician before anything ships
- Compounded by FDA-registered pharmacies, tested for purity
- Itemized at-cost pricing, no markup on the medicine
- Ongoing clinical support included in membership
Built around you, not a catalog.
The off-the-shelf way
- One fixed dose for everyone
- Opaque sticker price, hidden markup
- Buy it and you're on your own
- One delivery form, take it or leave it
- A catalog, no one reviewing your fit
The Pru way
- Dose titrated by your physician
- Medication at cost, itemized in full
- Ongoing clinical check-ins, included
- Form matched to your routine
- A physician reviews before it ships
Everything you need to know.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It plays a central role in how cells produce energy inside the mitochondria, and it is also involved in DNA repair and in activating sirtuins, a family of proteins tied to cellular maintenance. It is not a drug or a treatment on its own. It is a naturally occurring molecule that has been widely studied for its role in cellular metabolism.
Why do NAD+ levels matter?
Research has shown that NAD+ levels tend to decline as we age. Because NAD+ is involved in mitochondrial energy production, DNA repair, and sirtuin activity, scientists have studied whether supporting NAD+ levels may be relevant to how cells respond to aging. The science here is still developing, and lower NAD+ has not been established as the cause of any specific condition. Pru does not claim that NAD+ reverses aging or treats, cures, or prevents any disease.
How is NAD+ delivered at Pru?
NAD+ is prepared by FDA-registered compounding pharmacies and offered in three formats so your physician can match delivery to your situation: an aqueous (ready-to-use) injection, a lyophilized (freeze-dried) kit that is reconstituted before use, and a nasal spray. Which format makes sense, if any, is a clinical decision your physician makes after reviewing your intake. NAD+ is compounded, not a mass-manufactured FDA-approved drug product.
Who is NAD+ for?
NAD+ is part of Pru's Cellular Health & Longevity category, studied for its role in mitochondrial energy, DNA repair, and sirtuin pathways. It may be of interest to adults focused on cellular and longevity-oriented wellness, and it is not right for everyone. NAD+ is not FDA-approved for any specific indication, and any use is off-label and supportive in nature. Whether you are a candidate is determined by a licensed physician based on your health history, current medications, and goals.
Do I need a prescription?
Yes. Every peptide at Pru is physician-prescribed and dispensed through FDA-registered compounding pharmacies. There is no over-the-counter path. It starts with your membership, which unlocks a medical intake and a review by a licensed physician who decides whether it is appropriate for you.
Are peptides safe?
Peptides are prescription medications. They are compounded by FDA-registered pharmacies and tested for purity and sterility, and your physician reviews your health history to determine whether they are appropriate for you. They are not right for everyone, and individual results vary.
How long until I notice anything?
It varies by person and by peptide, and we will not promise a timeline. Your physician sets expectations during review and tracks how you respond over time. Some people describe changes over weeks to months; individual results vary.
Is lab work required?
It depends. Lab work is a clinical decision made by your physician, not a fixed requirement for everyone. During your intake and review, the physician determines whether labs are needed before prescribing, based on your individual situation, and will tell you what is needed and why.
More questions? Visit the help center.
Ready when you are
Start with NAD+.
Add it to your cart and complete a short intake. A physician confirms the fit. You only pay if it is prescribed.