Weight Loss & Metabolism
Semaglutide
Quiet the food noise. Lose meaningful weight, and keep it off.
A weekly GLP-1 injection that copies the gut hormone your body releases to tell your brain you are full, so constant appetite and cravings quiet down. Compounded at FDA-registered pharmacies; your physician picks the right strength during your consult.
- Physician-reviewed before it ships
- Prescription required
- $60/mo membership, cancel anytime
Semaglutide is a GLP-1 receptor agonist taken as a weekly subcutaneous injection. It copies the gut hormone your body releases to tell your brain you are full, and it slows how fast your stomach empties, so you feel satisfied sooner and for longer. The branded forms (Ozempic for type 2 diabetes, Wegovy for chronic weight management) are FDA-approved based on clinical trials. Pru provides compounded semaglutide, prepared at FDA-registered compounding pharmacies under physician prescription. Compounded semaglutide uses the same active ingredient as the branded versions but is not the same product and has not undergone identical clinical trials. Your physician determines candidacy based on your health profile.
For someone with meaningful weight to lose who fights constant appetite and food noise and wants a proven, powerful tool. It is an especially considered choice for anyone carrying added cardiovascular risk. If you have lost the weight before and watched it come back, or you are stuck at a plateau the scale will not budge, this is built for you.
Semaglutide works a single hormone pathway (GLP-1). Tirzepatide adds a second pathway (GIP) for a higher ceiling, so it tends to produce a larger average result. Choose semaglutide for a lower-cost start when you do not need to chase the maximum. The two are alternatives, not a stack: your physician prescribes one, never both together.
Studied for weight management support, appetite regulation, insulin sensitivity, and cardiovascular health markers. In clinical trials of the branded form, this pathway has been associated with substantial, durable weight loss over months. Research suggests its effect comes from quieting appetite and slowing gastric emptying. Individual results vary and require physician oversight.
Pick a starting option.
A starting point, not a final prescription. Your physician confirms the right form, strength, and dose during consultation, which can change the price you pay.
The medicine is one input. The program is the rest.
What you might notice, how you track it honestly, and how Pru and your clinician work with you. Individual results vary.
What you would notice
Many people describe the food noise and cravings quieting within the first few weeks, often before the scale moves much. If it works as intended, the constant pull toward snacking eases and meals feel like enough. Over the following months, the weight tends to come down as a steady trend rather than a daily drop. The first weeks and each dose step-up are also when GI side effects (nausea, constipation, diarrhea) are most likely, and they usually settle as your body adjusts.
How you track it
Watch your waist and how your clothes fit, not just the number on the scale. Run a simple food-noise check: is the urge to snack louder or quieter than last week? Treat weight as a rolling trend across days, never a single morning reading. Pru gives you the tools to log all three in one place, so you can see the real direction instead of reacting to daily noise.
How Pru works with you
Pru wraps the medicine in a program so it actually works for you. You get a titration-week protocol timed to the exact days your dose escalates, so step-ups are planned rather than a surprise. A protein floor and a resistance-training program help protect muscle while you lose fat. The motivation and habit engine is built to carry you through the dropout cliff where most people quit. And when you are ready, a structured taper helps your results survive a pause. Your clinician reviews how you are responding and adjusts the plan with you.
A horizon, personalized to you.
Not a promise. Your clinician personalizes the plan and tracks how you respond. Individual results vary.
- Weeks 1–2
Getting started
Your clinician sets a starting protocol and decides whether any initial titration is right for you. The early window is about onboarding and tolerability: dialing in dose, timing, and technique together.
- Weeks 3–6
Finding your rhythm
Many people describe settling into a consistent routine across these weeks while their clinician reviews how they are responding and adjusts as needed.
- Month 2+
Maintenance
Most protocols move to a steady maintenance cadence guided by your clinician. Check-ins are where dose, frequency, and format are reviewed against what you are noticing.
A physician reviews every order. The medicine is sold at cost.
You are not buying off a shelf. A licensed physician reviews your health profile and decides whether Semaglutide is right for you. If it is, you pay exactly what it costs us. The pharmacy fill, the supplies, your consult, shipping. Nothing on top. Your membership is the only thing you pay for.
- Reviewed by a licensed physician before anything ships
- Compounded by FDA-registered pharmacies, tested for purity
- Itemized at-cost pricing, no markup on the medicine
- Ongoing clinical support included in membership
Built around you, not a catalog.
The off-the-shelf way
- One fixed dose for everyone
- Opaque sticker price, hidden markup
- Buy it and you're on your own
- One delivery form, take it or leave it
- A catalog, no one reviewing your fit
The Pru way
- Dose titrated by your physician
- Medication at cost, itemized in full
- Ongoing clinical check-ins, included
- Form matched to your routine
- A physician reviews before it ships
Everything you need to know.
Do I need a prescription?
Yes. Every peptide at Pru is physician-prescribed and dispensed through FDA-registered compounding pharmacies. There is no over-the-counter path. It starts with your membership, which unlocks a medical intake and a review by a licensed physician who decides whether it is appropriate for you.
Are peptides safe?
Peptides are prescription medications. They are compounded by FDA-registered pharmacies and tested for purity and sterility, and your physician reviews your health history to determine whether they are appropriate for you. They are not right for everyone, and individual results vary.
How long until I notice anything?
It varies by person and by peptide, and we will not promise a timeline. Your physician sets expectations during review and tracks how you respond over time. Some people describe changes over weeks to months; individual results vary.
Is lab work required?
It depends. Lab work is a clinical decision made by your physician, not a fixed requirement for everyone. During your intake and review, the physician determines whether labs are needed before prescribing, based on your individual situation, and will tell you what is needed and why.
More questions? Visit the help center.
Ready when you are
Start with Semaglutide.
Add it to your cart and complete a short intake. A physician confirms the fit. You only pay if it is prescribed.